Oligopeptides as potential antiaggregation agents for deoxyhemoglobin S.

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Oligopeptides as potential antiaggregation agents for deoxyhemoglobin S.

Oligopeptides that mimic segments of the amino acid sequence of hemoglobin S at potential contact sites can be used to inhibit aggregation. These oligopeptide inhibitors raise the minimum gelling concentration of deoxyhemoglobin S so that chemical modification does not have to be used. The hexapeptide amides of both betaS 1-6 which is believed to be one of the contact areas among aggregates, an...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1977

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.74.12.5431